View source for 9g6c


==CLC7/OSTM1 complex with bound PIP2 lipid==
<StructureSection load='9g6c' size='340' side='right'caption='[[9g6c]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9g6c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9G6C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9G6C FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IIT:[(2~{R})-2-octanoyloxy-3-[oxidanyl-[(1~{S},2~{R},3~{S},4~{R},5~{R},6~{R})-2,4,5-tris(oxidanyl)-3,6-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl]+octanoate'>A1IIT</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9g6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9g6c OCA], [https://pdbe.org/9g6c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9g6c RCSB], [https://www.ebi.ac.uk/pdbsum/9g6c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9g6c ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CLCN7_HUMAN CLCN7_HUMAN] Albers-Schoenberg osteopetrosis;Autosomal recessive malignant osteopetrosis;Intermediate osteopetrosis. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/CLCN7_HUMAN CLCN7_HUMAN] Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity).[UniProtKB:P35523]<ref>PMID:18449189</ref> <ref>PMID:21527911</ref> <ref>PMID:31155284</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Deme JC]]
[[Category: Lea SM]]
[[Category: Lin Y]]
[[Category: Newstead S]]