View source for 9gdk


==Jumonji domain-containing protein 1C with crystallization epitope mutations L2440Y:G2444H==
<StructureSection load='9gdk' size='340' side='right'caption='[[9gdk]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9gdk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GDK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gdk OCA], [https://pdbe.org/9gdk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gdk RCSB], [https://www.ebi.ac.uk/pdbsum/9gdk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gdk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/JHD2C_HUMAN JHD2C_HUMAN] Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Burgess-Brown N]]
[[Category: Damerell D]]
[[Category: Edwards A]]
[[Category: Fairhead M]]
[[Category: Koekemoer L]]
[[Category: Krojer T]]
[[Category: MacLean EM]]
[[Category: Mackinnon SR]]
[[Category: Marsden B]]
[[Category: Pinkas D]]
[[Category: Strain-Damerell C]]
[[Category: Ye M]]
[[Category: Yue W]]
[[Category: Von Delft F]]