View source for 9gem


==Crystal structure of NUDT14 complexed with novel compound MA12==
<StructureSection load='9gem' size='340' side='right'caption='[[9gem]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9gem]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GEM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.015&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IJI:1-(1-methylpiperidin-4-yl)-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]pyrazolo[3,4-d]pyrimidin-4-amine'>A1IJI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gem OCA], [https://pdbe.org/9gem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gem RCSB], [https://www.ebi.ac.uk/pdbsum/9gem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gem ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NUD14_HUMAN NUD14_HUMAN] Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Adcock C]]
[[Category: Apostolidou M]]
[[Category: Dlamini LS]]
[[Category: Gurav N]]
[[Category: Huber KVM]]
[[Category: Koekemoer L]]
[[Category: McGown A]]
[[Category: Spencer J]]