View source for 9ges


==Crystal structure of HEI10==
<StructureSection load='9ges' size='340' side='right'caption='[[9ges]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ges]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GES FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ges FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ges OCA], [https://pdbe.org/9ges PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ges RCSB], [https://www.ebi.ac.uk/pdbsum/9ges PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ges ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CIP1_HUMAN CIP1_HUMAN] Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.<ref>PMID:12612082</ref> <ref>PMID:17297447</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Davies OR]]
[[Category: Dunce JM]]
[[Category: Espejo-Serrano C]]
[[Category: Milburn AE]]