View source for 9gex


==Escherichia coli NrdR with unocuppied outer nucleotide-binding site==
<StructureSection load='9gex' size='340' side='right'caption='[[9gex]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9gex]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GEX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gex OCA], [https://pdbe.org/9gex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gex RCSB], [https://www.ebi.ac.uk/pdbsum/9gex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gex ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NRDR_ECOLI NRDR_ECOLI] Represses transcription of the class Ib RNR genes nrdHIEF but has much smaller effect on transcription of the class Ia RNR genes nrdAB and class III RNR genes nrdDG. By binding to nrdR boxes in the promoter regions to alter promoter activity, nrdR differentially regulates nrdAB, nrdHIEF and nrdD transcription in aerobic growth.<ref>PMID:17496099</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Pedraz L]]
[[Category: Schmitz C]]
[[Category: Sola M]]
[[Category: Szura A]]
[[Category: Torrents E]]