View source for 9gih


==Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH14047==
<StructureSection load='9gih' size='340' side='right'caption='[[9gih]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9gih]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GIH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.271&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IL2:~{N}-(3,4-dichlorophenyl)-1~{H}-pyrazolo[3,4-b]pyridin-4-amine'>A1IL2</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gih OCA], [https://pdbe.org/9gih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gih RCSB], [https://www.ebi.ac.uk/pdbsum/9gih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gih ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OGG1_MOUSE OGG1_MOUSE] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Scaletti Hutchinson E]]
[[Category: Stenmark P]]