View source for 9gjg


==Entamoeba histolytica Gal/GalNAc lectin bound to monoclonal antibody CP33-H/L-LA22==
<StructureSection load='9gjg' size='340' side='right'caption='[[9gjg]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9gjg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Entamoeba_histolytica_HM-1:IMSS Entamoeba histolytica HM-1:IMSS] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GJG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GJG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gjg OCA], [https://pdbe.org/9gjg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gjg RCSB], [https://www.ebi.ac.uk/pdbsum/9gjg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gjg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HGL1_ENTH1 HGL1_ENTH1] Lectin which binds galactose and N-acetyl-D-galactosamine of host glycoproteins and thus mediates adhesion to host cells (Probable). Mediates adherence to host colonic mucins, an essential step for pathogenic tissue invasion (Probable).<ref>PMID:12142490</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Entamoeba histolytica HM-1:IMSS]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Gerard SF]]
[[Category: Higgins MK]]