View source for 9gjk


==Entamoeba histolytica Gal/GalNAc lectin bound to LacNAc, mode 1==
<StructureSection load='9gjk' size='340' side='right'caption='[[9gjk]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9gjk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Entamoeba_histolytica_HM-1:IMSS Entamoeba histolytica HM-1:IMSS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GJK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GJK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PRD_900019:N-acetyl-alpha-lactosamine'>PRD_900019</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gjk OCA], [https://pdbe.org/9gjk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gjk RCSB], [https://www.ebi.ac.uk/pdbsum/9gjk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gjk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HGL1_ENTH1 HGL1_ENTH1] Lectin which binds galactose and N-acetyl-D-galactosamine of host glycoproteins and thus mediates adhesion to host cells (Probable). Mediates adherence to host colonic mucins, an essential step for pathogenic tissue invasion (Probable).<ref>PMID:12142490</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Entamoeba histolytica HM-1:IMSS]]
[[Category: Large Structures]]
[[Category: Gerard SF]]
[[Category: Higgins MK]]