View source for 9got


==Partial (48mer) encapsulin shell assembly from Mycobacterium tuberculosis==
<StructureSection load='9got' size='340' side='right'caption='[[9got]], [[Resolution|resolution]] 5.42&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9got]] is a 48 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GOT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.42&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9got FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9got OCA], [https://pdbe.org/9got PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9got RCSB], [https://www.ebi.ac.uk/pdbsum/9got PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9got ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ENCAP_MYCTU ENCAP_MYCTU] Shell component of a type 1 encapsulin nanocompartment in situ; its cargo protects against oxidative stress at low pH. In situ and in E.coli assembles into proteinaceous shells about 22 nm in diameter with 2.5 nm thick walls (PubMed:24855650, PubMed:34751132). Cargo proteins are targeted to the interior via their C-terminal extensions; empty intact shells can be isolated in E.coli in the absence of cargo protein. There are at least 4 possible cargo proteins, DyP (encoded in the same locus), FolB, BfrB and Rv1762c; DyP and Rv1762c have been identified in vivo (PubMed:24855650). Probably involved in protection against oxidative damage from the host immune response (Probable) (PubMed:34751132). A T-cell antigen found in bacterial culture cell filtrates, stimulates mouse immune response. Does not have detectable bacteriocin activity (PubMed:9596740).<ref>PMID:24855650</ref> <ref>PMID:34751132</ref> <ref>PMID:9596740</ref> <ref>PMID:24855650</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Berger C]]
[[Category: Lewis CJ]]
[[Category: Ravelli RBG]]