View source for 9gsl


==Cryo-EM structure of human SLC35B1 in inward facing conformation==
<StructureSection load='9gsl' size='340' side='right'caption='[[9gsl]], [[Resolution|resolution]] 3.37&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9gsl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GSL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.37&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gsl OCA], [https://pdbe.org/9gsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gsl RCSB], [https://www.ebi.ac.uk/pdbsum/9gsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gsl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/S35B1_HUMAN S35B1_HUMAN] ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane. Imports ATP from the cytosol to the ER lumen and exports ADP in the opposite direction (PubMed:30154480, PubMed:35041824). Regulates ER energy metabolism and protein biogenesis. Appears to be part of a calcium-dependent ER to cytosol low energy response axis, where calcium efflux from ER to the cytosol triggers ATP import into the ER lumen to maintain sufficient ATP supply. Provides ATP to ER chaperone HSPA5 that drives protein folding and trafficking in the ER (PubMed:30154480, PubMed:35041824). Can transport dATP, UTP or UDP in exchange for ATP, but the physiological relevance of this process remains to be established (PubMed:30154480, PubMed:35041824).<ref>PMID:30154480</ref> <ref>PMID:35041824</ref>   ATP:ADP antiporter.<ref>PMID:30154480</ref> <ref>PMID:35041824</ref>   ATP:ADP antiporter.<ref>PMID:30154480</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Ahn D]]
[[Category: Drew D]]
[[Category: Gulati A]]
[[Category: Suades A]]