View source for 9gtb


==Cryo-EM structure of Mouse PMCA-NPTN complex captured in E1-Ca state==
<StructureSection load='9gtb' size='340' side='right'caption='[[9gtb]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9gtb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GTB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GTB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KXP:(2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl+icosa-5,8,11,14-tetraenoate'>KXP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gtb OCA], [https://pdbe.org/9gtb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gtb RCSB], [https://www.ebi.ac.uk/pdbsum/9gtb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gtb ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/AT2B2_MOUSE AT2B2_MOUSE] Defects in Atp2b2 are associated with early onset profound hearing loss and severe vestibular dysfunction.<ref>PMID:17234811</ref> <ref>PMID:9697703</ref> 
== Function ==
[https://www.uniprot.org/uniprot/AT2B2_MOUSE AT2B2_MOUSE] ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:17234811, PubMed:9668038). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics (PubMed:17409239, PubMed:20083513). At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (PubMed:17409239, PubMed:20083513). Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (By similarity) (PubMed:9668038). Regulates Ca(2+) signaling through dissipation of Ca(2+) transients generated by store-operated channels (By similarity). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (PubMed:15302868).[UniProtKB:Q01814]<ref>PMID:15302868</ref> <ref>PMID:17234811</ref> <ref>PMID:17409239</ref> <ref>PMID:20083513</ref> <ref>PMID:9668038</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Constantin CE]]
[[Category: Fakler B]]
[[Category: Prubaum D]]
[[Category: Raunser S]]
[[Category: Shulte U]]
[[Category: Sistel O]]
[[Category: Vinayagam D]]
[[Category: Zolles G]]