View source for 9gti


==X-ray crystal structure of mouse NPTN N-terminal domain==
<StructureSection load='9gti' size='340' side='right'caption='[[9gti]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9gti]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GTI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gti OCA], [https://pdbe.org/9gti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gti RCSB], [https://www.ebi.ac.uk/pdbsum/9gti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gti ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NPTN_MOUSE NPTN_MOUSE] Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity. Promotes localization of XKR8 at the cell membrane (By similarity).[UniProtKB:P97546][UniProtKB:Q9Y639]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Constantin CE]]
[[Category: Fakler B]]
[[Category: Prubaum D]]
[[Category: Raunser S]]
[[Category: Shulte U]]
[[Category: Sistel O]]
[[Category: Vinayagam D]]
[[Category: Zolles G]]