View source for 9gvu


==Human Rab27A in complex with cyclic peptide IMP-2660==
<StructureSection load='9gvu' size='340' side='right'caption='[[9gvu]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9gvu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GVU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTY:D-TYROSINE'>DTY</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=XAK:2-[(2~{R})-2-azanyl-3-[(2-azanyl-2-oxidanylidene-ethyl)amino]-3-oxidanylidene-propyl]sulfanylethanoic+acid'>XAK</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gvu OCA], [https://pdbe.org/9gvu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gvu RCSB], [https://www.ebi.ac.uk/pdbsum/9gvu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gvu ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/RB27A_HUMAN RB27A_HUMAN] Griscelli syndrome type 2. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/RB27A_HUMAN RB27A_HUMAN] Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.<ref>PMID:18812475</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Cota E]]
[[Category: De Vita E]]
[[Category: Morgan MR]]
[[Category: Petracca R]]
[[Category: Tate EW]]
[[Category: Tersa M]]