View source for 9hcl


==Crystal structure of human TRF1 TRFH domain in complex with compound 12==
<StructureSection load='9hcl' size='340' side='right'caption='[[9hcl]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9hcl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HCL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TWC:2-ethyl-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one'>TWC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hcl OCA], [https://pdbe.org/9hcl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hcl RCSB], [https://www.ebi.ac.uk/pdbsum/9hcl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hcl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TERF1_HUMAN TERF1_HUMAN] Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.<ref>PMID:16166375</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Casale G]]
[[Category: Guettler S]]
[[Category: Le Bihan Y-V]]
[[Category: Van Montfort RLM]]