View source for 9hde


==Crystal structure of methionine gamma-lyase (K209Q variant) from Brevibacterium aurantiacum in complex with PLP and alpha-ketobutyrate==
<StructureSection load='9hde' size='340' side='right'caption='[[9hde]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9hde]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevibacterium Brevibacterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HDE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HDE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.522&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4LM:(2E)-2-{[(1E)-{3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYLIDENE]AMINO}BUT-2-ENOIC+ACID'>4LM</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hde OCA], [https://pdbe.org/9hde PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hde RCSB], [https://www.ebi.ac.uk/pdbsum/9hde PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hde ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MEGL_BREAU MEGL_BREAU] Catalyzes the alpha,gamma-elimination of L-methionine to produce methanethiol, 2-oxobutanoate and ammonia (PubMed:30940696, PubMed:9726878). May be responsible for the production of methanethiol associated with desirable Cheddar-type sulfur notes during cheese ripening (Probable). Is also able to catalyze the alpha,gamma-elimination of L-homocysteine and DL-selenomethionine, but has no activity toward L-cysteine, L-cystathionine, S-adenosyl-L-homocysteine and D-methionine (PubMed:30940696, PubMed:9726878).<ref>PMID:30940696</ref> <ref>PMID:9726878</ref> <ref>PMID:9726878</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Brevibacterium]]
[[Category: Large Structures]]
[[Category: Briozzo P]]
[[Category: Ferchaud N]]
[[Category: Kopecny D]]