View source for 9hef


==Crystal Structure of MfpD from Mycobacterium tuberculosis==
<StructureSection load='9hef' size='340' side='right'caption='[[9hef]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9hef]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HEF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hef OCA], [https://pdbe.org/9hef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hef RCSB], [https://www.ebi.ac.uk/pdbsum/9hef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hef ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPI_MYCTU SPI_MYCTU] Effector protein that binds to the host serine protease cathepsin G on the macrophage cell membrane, inhibiting its enzymatic activity and the downstream activation of caspase-1-dependent apoptosis. Thus prevents macrophage pyroptosis and helps M.tuberculosis survival within host cells.<ref>PMID:22275911</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Haouz A]]
[[Category: Micaletto M]]
[[Category: Petrella S]]