View source for 9hft


==Cryo-EM structure of human CDADC1 inactive mutant (E400A): hexamer with 5mdCTP bound in the active site==
<StructureSection load='9hft' size='340' side='right'caption='[[9hft]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9hft]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HFT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1I2I:[[(2~{R},3~{S},5~{R})-5-(4-azanyl-5-methyl-2-oxidanylidene-pyrimidin-1-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+phosphono+hydrogen+phosphate'>A1I2I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hft OCA], [https://pdbe.org/9hft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hft RCSB], [https://www.ebi.ac.uk/pdbsum/9hft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hft ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CDAC1_HUMAN CDAC1_HUMAN] Catalyzes the deamination of cytidine and deoxycytidine into uridine and deoxyuridine, respectively (PubMed:26945630). May play an important role in testicular development and spermatogenesis (PubMed:16955368).<ref>PMID:16955368</ref> <ref>PMID:26945630</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bochtler M]]
[[Category: Czarnocki-Cieciura M]]
[[Category: Kanai T]]
[[Category: Lountos G]]
[[Category: Rathore I]]
[[Category: Skowronek K]]
[[Category: Slyvka A]]
[[Category: Wang Z]]
[[Category: Wlodawer A]]
[[Category: Yang R]]