View source for 9hgi


==HSV-1 Origin Binding Protein in complex with double-stranded DNA recognition sequence OriS with 6 basepairs removed from the AT-rich region==
<StructureSection load='9hgi' size='340' side='right'caption='[[9hgi]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9hgi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_KOS Human alphaherpesvirus 1 strain KOS] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HGI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.77&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hgi OCA], [https://pdbe.org/9hgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hgi RCSB], [https://www.ebi.ac.uk/pdbsum/9hgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hgi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/D3YPE9_HHV1F D3YPE9_HHV1F] Functions as a docking protein to recruit essential components of the viral replication machinery to viral DNA origins. In the presence of the major DNA-binding protein, opens dsDNA leading to a conformational change in the origin that facilitates DNA unwinding and subsequent replication.[ARBA:ARBA00025279]
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</StructureSection>
[[Category: Human alphaherpesvirus 1 strain KOS]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Elias P]]
[[Category: Grunewald K]]
[[Category: Gustavsson E]]
[[Category: Hallberg BM]]