View source for 9hhq


==Human monocarboxylate transporter 10==
<StructureSection load='9hhq' size='340' side='right'caption='[[9hhq]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9hhq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HHQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hhq OCA], [https://pdbe.org/9hhq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hhq RCSB], [https://www.ebi.ac.uk/pdbsum/9hhq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hhq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MOT10_HUMAN MOT10_HUMAN] Sodium- and proton-independent thyroid hormones and aromatic acids transporter (PubMed:11827462, PubMed:18337592, PubMed:28754537). Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (PubMed:18337592). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed:11827462, PubMed:28754537). Plays an important role in homeostasis of aromatic amino acids (By similarity).[UniProtKB:Q3U9N9]<ref>PMID:11827462</ref> <ref>PMID:18337592</ref> <ref>PMID:28754537</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bagenholm V]]
[[Category: Gourdon PE]]
[[Category: Nordlin KP]]