View source for 9hhs


==Crystal Structure of the Coxiella burnetii R152Q Mutant 2-methylisocitrate lyase==
<StructureSection load='9hhs' size='340' side='right'caption='[[9hhs]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9hhs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxiella_burnetii Coxiella burnetii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HHS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hhs OCA], [https://pdbe.org/9hhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hhs RCSB], [https://www.ebi.ac.uk/pdbsum/9hhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hhs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q83DG5_COXBU Q83DG5_COXBU] Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.[RuleBase:RU361121]  Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.[HAMAP-Rule:MF_01939]  Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.[ARBA:ARBA00057039]
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</StructureSection>
[[Category: Coxiella burnetii]]
[[Category: Large Structures]]
[[Category: Harmer NJ]]
[[Category: Isupov M]]
[[Category: Stuart W]]