View source for 9hma


==Cryo-EM structure of apo human separase==
<StructureSection load='9hma' size='340' side='right'caption='[[9hma]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9hma]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HMA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HMA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hma FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hma OCA], [https://pdbe.org/9hma PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hma RCSB], [https://www.ebi.ac.uk/pdbsum/9hma PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hma ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ESPL1_HUMAN ESPL1_HUMAN] Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.<ref>PMID:10411507</ref> <ref>PMID:11509732</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Boland A]]
[[Category: Botto M]]
[[Category: Schmidt S]]
[[Category: Yu J]]