View source for 9hmh


==Crystal structure of the Calf domains of Integrin Alpha5==
<StructureSection load='9hmh' size='340' side='right'caption='[[9hmh]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9hmh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HMH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hmh OCA], [https://pdbe.org/9hmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hmh RCSB], [https://www.ebi.ac.uk/pdbsum/9hmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hmh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ITA5_HUMAN ITA5_HUMAN] Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Leppanen VML]]
[[Category: Murthy AV]]
[[Category: Ponna SK]]
[[Category: Saharinen PI]]
[[Category: Sipila TJO]]