View source for 9hqh


==SARM1 TIR domain in complex with compound 28-ADPR==
<StructureSection load='9hqh' size='340' side='right'caption='[[9hqh]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9hqh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HQH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.988&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IWN:[[(3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+[(2~{R},3~{S},4~{R},5~{R})-5-[4-[(1~{R})-1-[[(3~{R})-4,4-bis(fluoranyl)oxolan-3-yl]carbamoyl-methyl-amino]-2-phenoxy-ethyl]pyridin-1-ium-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl+hydrogen+phosphate'>A1IWN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hqh OCA], [https://pdbe.org/9hqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hqh RCSB], [https://www.ebi.ac.uk/pdbsum/9hqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hqh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SARM1_HUMAN SARM1_HUMAN] Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.<ref>PMID:15123841</ref> <ref>PMID:16964262</ref> <ref>PMID:16985498</ref> <ref>PMID:20306472</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Aregger N]]
[[Category: Benz J]]
[[Category: Bilyard M]]
[[Category: Bonardi C]]
[[Category: Brigo A]]
[[Category: Burger D]]
[[Category: Caramenti P]]
[[Category: Gasser C]]
[[Category: Giroud M]]
[[Category: Grether U]]
[[Category: Haap W]]
[[Category: Haider A]]
[[Category: Hilbert M]]
[[Category: Kalayil S]]
[[Category: Keaney J]]
[[Category: Kuhn B]]
[[Category: Malnight-Alvarez A]]
[[Category: Mani A]]
[[Category: Mendel M]]
[[Category: Pinard E]]
[[Category: Plitzko I]]
[[Category: Ritter M]]
[[Category: Rombach D]]
[[Category: Saal W]]
[[Category: Schmid P]]
[[Category: Sechet N]]
[[Category: Steiner S]]
[[Category: Topp A]]
[[Category: Westwood P]]
[[Category: Wittwer M]]
[[Category: Zambaldo C]]