View source for 9hqm


==T-Muurolol Synthase from Roseiflexus castenholzii (TmS) in complex with FSPP==
<StructureSection load='9hqm' size='340' side='right'caption='[[9hqm]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9hqm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Roseiflexus_castenholzii Roseiflexus castenholzii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HQM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hqm OCA], [https://pdbe.org/9hqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hqm RCSB], [https://www.ebi.ac.uk/pdbsum/9hqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hqm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TMUUS_ROSCS TMUUS_ROSCS] Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) into (+)-T-muurolol via a 1,10-cyclization, which requires isomerization of FPP to nerolidyl diphosphate (NPP) and then abstraction of the pyrophosphate from intermediate NPP leading to a (E,Z)-germacradienyl (helminthogermacradienyl) cation.<ref>PMID:23307484</ref> <ref>PMID:27666571</ref> <ref>PMID:27829890</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Roseiflexus castenholzii]]
[[Category: Dickschat JS]]
[[Category: Groll M]]
[[Category: Li H]]
[[Category: Troycke P]]