View source for 9hv7


==Crystal structure of Tetraspanin TSPAN10mutant Large Extracellular Loop (LEL)==
<StructureSection load='9hv7' size='340' side='right'caption='[[9hv7]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9hv7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HV7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hv7 OCA], [https://pdbe.org/9hv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hv7 RCSB], [https://www.ebi.ac.uk/pdbsum/9hv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hv7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TSN10_HUMAN TSN10_HUMAN] Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates.<ref>PMID:37516108</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Krey T]]
[[Category: Nagarathinam K]]