View source for 9hx8


==Apo structure of SRSF6 RRM2 W123A==
<StructureSection load='9hx8' size='340' side='right'caption='[[9hx8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9hx8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HX8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hx8 OCA], [https://pdbe.org/9hx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hx8 RCSB], [https://www.ebi.ac.uk/pdbsum/9hx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hx8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SRSF6_HUMAN SRSF6_HUMAN] Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.<ref>PMID:12549914</ref> <ref>PMID:15009664</ref> <ref>PMID:22767602</ref> <ref>PMID:24440982</ref> [https://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST] Not known; suppressor of MIF2 mutations.
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Schlundt A]]
[[Category: Von Ehr J]]