View source for 9i2s


==Velvet domain of the transcriptional regulator VeA==
<StructureSection load='9i2s' size='340' side='right'caption='[[9i2s]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9i2s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_nidulans Aspergillus nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9I2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9I2S FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9i2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9i2s OCA], [https://pdbe.org/9i2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9i2s RCSB], [https://www.ebi.ac.uk/pdbsum/9i2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9i2s ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VEA_EMENI VEA_EMENI] Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (PubMed:12223191, PubMed:14665453, PubMed:18556559, PubMed:19210625, PubMed:2076818, PubMed:2253875). The velvet complex acts as a global regulator for secondary metabolite gene expression (PubMed:18556559). Controls the expression of the sterigmatocystin and penicillin gene clusters (PubMed:14665453, PubMed:17375284). Represses the cryptic ors gene cluster producing orsellinic acid and its F9775 derivatives in a laeA-independent manner (PubMed:23841751). Required for full induction of faoA gene expression by fructosyl amines (PubMed:12375102). Positively regulates the expression of the early sexual development gene esdC (PubMed:17977758). Controls the expression of mannoprotein mnpA (PubMed:12620259).<ref>PMID:12223191</ref> <ref>PMID:12375102</ref> <ref>PMID:12620259</ref> <ref>PMID:14665453</ref> <ref>PMID:17977758</ref> <ref>PMID:18556559</ref> <ref>PMID:19210625</ref> <ref>PMID:2076818</ref> <ref>PMID:2253875</ref> <ref>PMID:23841751</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Aspergillus nidulans]]
[[Category: Large Structures]]
[[Category: Ficner R]]
[[Category: Neumann P]]