View source for 9i68


==Crystal structure of human Cdc20 bound to synthetic D-box peptide D21==
<StructureSection load='9i68' size='340' side='right'caption='[[9i68]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9i68]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9I68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9I68 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.505&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3EG:(2S)-2-AMINO-4,4,4-TRIFLUOROBUTANOIC+ACID'>3EG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9i68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9i68 OCA], [https://pdbe.org/9i68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9i68 RCSB], [https://www.ebi.ac.uk/pdbsum/9i68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9i68 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CDC20_HUMAN CDC20_HUMAN] Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.<ref>PMID:9811605</ref> <ref>PMID:9734353</ref> <ref>PMID:9637688</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Barford D]]
[[Category: Eapen R]]
[[Category: Ferrer F]]
[[Category: Fisher EJ]]
[[Category: Itzhaki LS]]
[[Category: Lindon C]]
[[Category: Okoye C]]
[[Category: Phillips C]]
[[Category: Schimpl M]]
[[Category: Spring D]]
[[Category: Stubbs C]]
[[Category: Tischer T]]
[[Category: Zacharopoulou M]]