View source for 9imz


==CODANIN-1 sequesters ASF1 by using a histone H3 mimic helix to regulate histone supply==
<StructureSection load='9imz' size='340' side='right'caption='[[9imz]], [[Resolution|resolution]] 3.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9imz]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IMZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.75&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9imz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9imz OCA], [https://pdbe.org/9imz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9imz RCSB], [https://www.ebi.ac.uk/pdbsum/9imz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9imz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ASF1A_HUMAN ASF1A_HUMAN] Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.<ref>PMID:10759893</ref> <ref>PMID:11897662</ref> <ref>PMID:12842904</ref> <ref>PMID:14718166</ref> <ref>PMID:15621527</ref> <ref>PMID:16151251</ref> <ref>PMID:15664198</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Frater RCM]]
[[Category: Groth A]]
[[Category: Jeong TK]]
[[Category: Song JJ]]
[[Category: Yoon J]]