View source for 9iyy


==Structure of HBsAg in complex with Fab H006==
<StructureSection load='9iyy' size='340' side='right'caption='[[9iyy]], [[Resolution|resolution]] 3.13&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9iyy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/HBV_genotype_D3 HBV genotype D3] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IYY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.13&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9iyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9iyy OCA], [https://pdbe.org/9iyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9iyy RCSB], [https://www.ebi.ac.uk/pdbsum/9iyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9iyy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/V9P415_HBV V9P415_HBV] The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.[HAMAP-Rule:MF_04075]  The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.[HAMAP-Rule:MF_04075]
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</StructureSection>
[[Category: HBV genotype D3]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chen L]]
[[Category: He X]]