View source for 9izh


==Cryo-EM structure of LPA1-G13 complex with LPA==
<StructureSection load='9izh' size='340' side='right'caption='[[9izh]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9izh]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IZH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.04&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NKP:(2R)-2-HYDROXY-3-(PHOSPHONOOXY)PROPYL+(9E)-OCTADEC-9-ENOATE'>NKP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9izh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9izh OCA], [https://pdbe.org/9izh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9izh RCSB], [https://www.ebi.ac.uk/pdbsum/9izh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9izh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LPAR1_HUMAN LPAR1_HUMAN] Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation.<ref>PMID:19306925</ref> [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Synthetic construct]]
[[Category: Fujiyoshi Y]]
[[Category: Hiroaki Y]]
[[Category: Kamegawa A]]
[[Category: Nishikawa K]]
[[Category: Suzuki H]]
[[Category: Suzuki S]]