View source for 9j4f


==Cryo-EM structure of P25alpha full-length A119V fibril==
<StructureSection load='9j4f' size='340' side='right'caption='[[9j4f]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9j4f]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9J4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9J4F FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.49&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9j4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9j4f OCA], [https://pdbe.org/9j4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9j4f RCSB], [https://www.ebi.ac.uk/pdbsum/9j4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9j4f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TPPP_HUMAN TPPP_HUMAN] Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887, PubMed:33831707). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed:21316364, PubMed:21995432). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:17105200, PubMed:17693641, PubMed:18028908, PubMed:26289831). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed:20308065, PubMed:23093407). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed:23093407). Plays a role in cell proliferation by regulating the G1/S-phase transition (PubMed:23355470). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed:22328514).<ref>PMID:17105200</ref> <ref>PMID:17693641</ref> <ref>PMID:18028908</ref> <ref>PMID:20308065</ref> <ref>PMID:21316364</ref> <ref>PMID:21995432</ref> <ref>PMID:22328514</ref> <ref>PMID:23093407</ref> <ref>PMID:23355470</ref> <ref>PMID:26289831</ref> <ref>PMID:31522887</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Huang CA]]
[[Category: Liu C]]
[[Category: Sun YP]]
[[Category: Xia WC]]