View source for 9jbr


==P5A-ATPase ATP13A1 D533N mutant==
<StructureSection load='9jbr' size='340' side='right'caption='[[9jbr]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9jbr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JBR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JBR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jbr OCA], [https://pdbe.org/9jbr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jbr RCSB], [https://www.ebi.ac.uk/pdbsum/9jbr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jbr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AT131_HUMAN AT131_HUMAN] Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed:32973005, PubMed:36264797). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed:32973005). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed:32973005).<ref>PMID:32973005</ref> <ref>PMID:36264797</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Li Y]]
[[Category: Liao J]]