View source for 9jea


==cryo-EM structure of M1 muscarinic acetylcholine receptor in complex with atropine==
<StructureSection load='9jea' size='340' side='right'caption='[[9jea]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9jea]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JEA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EBT:[(1~{R},5~{S})-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]+(2~{S})-3-oxidanyl-2-phenyl-propanoate'>A1EBT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jea OCA], [https://pdbe.org/9jea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jea RCSB], [https://www.ebi.ac.uk/pdbsum/9jea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jea ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ACM1_HUMAN ACM1_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Gao K]]
[[Category: Liu X]]
[[Category: Zhang X]]