View source for 9jec


==Cryo-EM structure of canine TNF-alpha complexed with nanobody TNF30K==
<StructureSection load='9jec' size='340' side='right'caption='[[9jec]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9jec]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JEC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jec OCA], [https://pdbe.org/9jec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jec RCSB], [https://www.ebi.ac.uk/pdbsum/9jec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jec ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TNFA_CANLF TNFA_CANLF] Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Promotes osteoclastogenesis and therefore mediates bone resorption (By similarity).[UniProtKB:P01375][UniProtKB:P06804]  The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.[UniProtKB:P01375]
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</StructureSection>
[[Category: Canis lupus familiaris]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Li Z]]
[[Category: Wei Z]]
[[Category: Weng J]]
[[Category: Xu J]]