View source for 9jg4


==Structure of Apo human Taurine transporter TauT in saposin nanodiscs at inward open conformation==
<StructureSection load='9jg4' size='340' side='right'caption='[[9jg4]], [[Resolution|resolution]] 3.02&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9jg4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JG4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.02&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jg4 OCA], [https://pdbe.org/9jg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jg4 RCSB], [https://www.ebi.ac.uk/pdbsum/9jg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jg4 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SC6A6_HUMAN SC6A6_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/SC6A6_HUMAN SC6A6_HUMAN] Mediates sodium- and chloride-dependent transport of taurine (PubMed:31345061, PubMed:31903486, PubMed:8010975, PubMed:8382624, PubMed:8654117). Mediates transport of beta-alanine (PubMed:8010975). Can also mediate transport of hypotaurine and gamma-aminobutyric acid (GABA) (By similarity).[UniProtKB:O35316]<ref>PMID:31345061</ref> <ref>PMID:31903486</ref> <ref>PMID:8010975</ref> <ref>PMID:8382624</ref> <ref>PMID:8654117</ref>   Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.<ref>PMID:31345061</ref> <ref>PMID:31903486</ref> <ref>PMID:8382624</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cui NN]]
[[Category: Xu EH]]
[[Category: Zhang H]]