View source for 9jic


==Cryo-EM Structure of the apo HCAR3-Gi complex==
<StructureSection load='9jic' size='340' side='right'caption='[[9jic]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9jic]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JIC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jic OCA], [https://pdbe.org/9jic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jic RCSB], [https://www.ebi.ac.uk/pdbsum/9jic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jic ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HCAR3_HUMAN HCAR3_HUMAN] Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.<ref>PMID:12522134</ref> <ref>PMID:19561068</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fang Y]]