View source for 9jk7


==Human VANGL2 hexamer==
<StructureSection load='9jk7' size='340' side='right'caption='[[9jk7]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9jk7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JK7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jk7 OCA], [https://pdbe.org/9jk7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jk7 RCSB], [https://www.ebi.ac.uk/pdbsum/9jk7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jk7 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/VANG2_HUMAN VANG2_HUMAN] Isolated anencephaly;Isolated exencephaly. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/VANG2_HUMAN VANG2_HUMAN] Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity).[UniProtKB:Q91ZD4]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Jian S]]
[[Category: Song Y]]
[[Category: Zhang Z]]
[[Category: Zheng P]]