View source for 9jsu


==Wild-type native PMEL amyloid - polymorph 2==
<StructureSection load='9jsu' size='340' side='right'caption='[[9jsu]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9jsu]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JSU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jsu OCA], [https://pdbe.org/9jsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jsu RCSB], [https://www.ebi.ac.uk/pdbsum/9jsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jsu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PMEL_HUMAN PMEL_HUMAN] Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.<ref>PMID:11694580</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Oda T]]
[[Category: Yanagisawa H]]