View source for 9jub


==Cryo-EM structure of human hyaluronidase PH-20==
<StructureSection load='9jub' size='340' side='right'caption='[[9jub]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9jub]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JUB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jub OCA], [https://pdbe.org/9jub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jub RCSB], [https://www.ebi.ac.uk/pdbsum/9jub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jub ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HYALP_HUMAN HYALP_HUMAN] Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.<ref>PMID:8282124</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Im S-B]]
[[Category: Jeong T-K]]
[[Category: Kim N]]
[[Category: Oh B-H]]