View source for 9jyx


==Crystal structure of Nir2 DDHD domain==
<StructureSection load='9jyx' size='340' side='right'caption='[[9jyx]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9jyx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JYX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.798&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jyx OCA], [https://pdbe.org/9jyx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jyx RCSB], [https://www.ebi.ac.uk/pdbsum/9jyx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jyx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PITM1_HUMAN PITM1_HUMAN] Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:10531358, PubMed:22822086). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086). Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959). Necessary for normal completion of cytokinesis (PubMed:15125835). Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272). Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057). Binds calcium ions (PubMed:10022914).<ref>PMID:10022914</ref> <ref>PMID:10531358</ref> <ref>PMID:11909959</ref> <ref>PMID:15545272</ref> <ref>PMID:15723057</ref> <ref>PMID:22822086</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kim D]]
[[Category: Lee C]]