View source for 9jzq


==The glycoprotein E of Varicella-Zoster Virus in complex with WLL-1/WLL-28 Fab==
<StructureSection load='9jzq' size='340' side='right'caption='[[9jzq]], [[Resolution|resolution]] 3.48&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9jzq]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_herpesvirus_3_strain_Oka_vaccine Human herpesvirus 3 strain Oka vaccine]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JZQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.48&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jzq OCA], [https://pdbe.org/9jzq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jzq RCSB], [https://www.ebi.ac.uk/pdbsum/9jzq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jzq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GE_VZVO GE_VZVO] Envelope glycoprotein that binds to the potential host cell entry receptor IDE.  In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips (By similarity).  The heterodimer gE/gI serves as a receptor for the Fc part of host IgG. Dissociation of gE/gI from IgG occurs at acidic pH. May thus be involved in anti-VZV antibodies bipolar bridging, followed by intracellular endocytosis and degradation, thereby interfering with host IgG-mediated immune responses (By similarity).
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Human herpesvirus 3 strain Oka vaccine]]
[[Category: Large Structures]]
[[Category: Guo Y]]
[[Category: Wang L]]
[[Category: Zhang N]]