View source for 9kbf


==Cryo-EM structure of the SKP1-FBXO3 complex==
<StructureSection load='9kbf' size='340' side='right'caption='[[9kbf]], [[Resolution|resolution]] 3.74&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9kbf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KBF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.74&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kbf OCA], [https://pdbe.org/9kbf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kbf RCSB], [https://www.ebi.ac.uk/pdbsum/9kbf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kbf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SKP1_HUMAN SKP1_HUMAN] Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.<ref>PMID:16209941</ref> <ref>PMID:20181953</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Wei J]]
[[Category: Xu C]]