View source for 9kgt


==Crystal structure of topoisomerase IV from Klebsiella pneumoniae in complex with DNA and BWC0977, a dual-targeting broad-spectrum novel bacterial topoisomerase inhibitor.==
<StructureSection load='9kgt' size='340' side='right'caption='[[9kgt]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9kgt]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae_subsp._pneumoniae_MGH_78578 Klebsiella pneumoniae subsp. pneumoniae MGH 78578] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KGT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1L5V:6-[(5~{S})-5-[[2-(7-fluoranyl-1-methyl-2-oxidanylidene-quinolin-8-yl)ethylamino]methyl]-2-oxidanylidene-1,3-oxazolidin-3-yl]-4~{H}-pyrazino[2,3-b][1,4]oxazin-3-one'>A1L5V</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kgt OCA], [https://pdbe.org/9kgt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kgt RCSB], [https://www.ebi.ac.uk/pdbsum/9kgt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kgt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A6TE12_KLEP7 A6TE12_KLEP7] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.[HAMAP-Rule:MF_00936][https://www.uniprot.org/uniprot/A6TE19_KLEP7 A6TE19_KLEP7] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.[HAMAP-Rule:MF_00938]
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</StructureSection>
[[Category: Klebsiella pneumoniae subsp. pneumoniae MGH 78578]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Aoki M]]
[[Category: Balasubramanian V]]
[[Category: Datta S]]
[[Category: Hameed S]]
[[Category: Katagihallimath N]]
[[Category: Murakami S]]
[[Category: Okada U]]
[[Category: Ramachandran V]]
[[Category: Yamashita E]]