View source for 9kr8


==Overall structure of HKU5 S protein in closed conformation==
<StructureSection load='9kr8' size='340' side='right'caption='[[9kr8]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9kr8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pipistrellus_bat_coronavirus_HKU5 Pipistrellus bat coronavirus HKU5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KR8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.39&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kr8 OCA], [https://pdbe.org/9kr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kr8 RCSB], [https://www.ebi.ac.uk/pdbsum/9kr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kr8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPIKE_BCHK5 SPIKE_BCHK5] S1 region attaches the virion to the cell membrane by interacting with cell receptors, initiating the infection.  S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity).
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pipistrellus bat coronavirus HKU5]]
[[Category: Xia LY]]
[[Category: Zhang YY]]
[[Category: Zhou Q]]