View source for 9kri


==human creatine transporter==
<StructureSection load='9kri' size='340' side='right'caption='[[9kri]], [[Resolution|resolution]] 3.39&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9kri]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KRI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KRI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.39&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1D9S:3-carbamimidamidopropanoic+acid'>A1D9S</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kri OCA], [https://pdbe.org/9kri PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kri RCSB], [https://www.ebi.ac.uk/pdbsum/9kri PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kri ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SC6A8_HUMAN SC6A8_HUMAN] X-linked creatine transporter deficiency. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/SC6A8_HUMAN SC6A8_HUMAN] Creatine:sodium symporter which mediates the uptake of creatine (PubMed:17465020, PubMed:22644605, PubMed:25861866, PubMed:7945388, PubMed:7953292, PubMed:9882430). Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity).[UniProtKB:Q8VBW1]<ref>PMID:17465020</ref> <ref>PMID:22644605</ref> <ref>PMID:25861866</ref> <ref>PMID:7945388</ref> <ref>PMID:7953292</ref> <ref>PMID:9882430</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chen JH]]
[[Category: Ge JP]]
[[Category: Yu J]]