View source for 9krp


==Structure of the HCV IRES-dependent 48S translation initiation complex with eIF5B and eIF3==
<StructureSection load='9krp' size='340' side='right'caption='[[9krp]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9krp]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KRP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9krp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9krp OCA], [https://pdbe.org/9krp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9krp RCSB], [https://www.ebi.ac.uk/pdbsum/9krp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9krp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RSSA_HUMAN RSSA_HUMAN] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.<ref>PMID:6300843</ref> <ref>PMID:16263087</ref> <ref>PMID:15516338</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Imami K]]
[[Category: Imataka H]]
[[Category: Ito T]]
[[Category: Iwasaki S]]
[[Category: Iwasaki W]]
[[Category: Kashiwagi K]]
[[Category: Machida K]]
[[Category: Matsumoto A]]
[[Category: Nishimoto M]]
[[Category: Sakamoto A]]
[[Category: Shichino Y]]
[[Category: Takahashi M]]