View source for 9ktm


==Alpha-hemolysin heptameric pre-pore state bound to 10:PC lipid chains derived from 10:0 PC liposomes.==
<StructureSection load='9ktm' size='340' side='right'caption='[[9ktm]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ktm]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KTM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P1O:1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>P1O</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ktm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ktm OCA], [https://pdbe.org/9ktm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ktm RCSB], [https://www.ebi.ac.uk/pdbsum/9ktm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ktm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HLA_STAAU HLA_STAAU] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Chatterjee A]]
[[Category: Dutta S]]
[[Category: Roy A]]