View source for 9kto


==Alpha-hemolysin heptameric late pre-pore state with bound lipids derived from 10:0 PC/Sphingomyelin liposomes==
<StructureSection load='9kto' size='340' side='right'caption='[[9kto]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9kto]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KTO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P1O:1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>P1O</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kto OCA], [https://pdbe.org/9kto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kto RCSB], [https://www.ebi.ac.uk/pdbsum/9kto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kto ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HLA_STAAU HLA_STAAU] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Chatterjee A]]
[[Category: Dutta S]]
[[Category: Roy A]]