View source for 9ktz


==Cryo-EM structure of the TIA-1 prion-like domain amyloid fibril, G355R==
<StructureSection load='9ktz' size='340' side='right'caption='[[9ktz]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9ktz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KTZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KTZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ktz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ktz OCA], [https://pdbe.org/9ktz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ktz RCSB], [https://www.ebi.ac.uk/pdbsum/9ktz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ktz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TIA1_HUMAN TIA1_HUMAN] Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ekari M]]
[[Category: Imamura K]]
[[Category: Inaoka D]]
[[Category: Kato T]]
[[Category: Kobayashi R]]
[[Category: Kodama ST]]
[[Category: Makino F]]
[[Category: Miyata T]]
[[Category: Namba K]]
[[Category: Ohtani Y]]
[[Category: Sakamoto E]]
[[Category: Sekiyama N]]
[[Category: Tochio H]]
[[Category: Yoshida N]]